Use of salivary cortisol and cortisone in the high- and low-dose synacthen test.
Clin Endocrinol (Oxf)
; 88(6): 772-778, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29106701
ABSTRACT
CONTEXT Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary cortisol at lower values of serum cortisol and is noninvasive. OBJECTIVE:
To investigate the relationship between serum cortisol and salivary cortisol and cortisone following low- and high-dose synacthen. DESIGN ANDSETTING:
Prospective pharmacodynamic studies in clinical research facilities. PARTICIPANTS AND INTERVENTION Thirty-five dexamethasone-suppressed, healthy adult males underwent an intravenous synacthen test N = 23 low-dose (1 mcg), N = 12 high-dose (250 mcg). Paired serum and salivary samples were taken at 15 sampling points over 120 minutes. MAIN OUTCOMEMEASURE:
Serum cortisol and salivary cortisol and cortisone were analysed for correlations and by a mixed-effects model.RESULTS:
At baseline, the correlation between serum cortisol and salivary cortisol was weak with many samples undetectable (r = .45, NS), but there was a strong correlation with salivary cortisone (r = .94, P < .001). Up to 50 minutes following synacthen, the correlation coefficient between serum cortisol and salivary cortisol and cortisone was <0.8, but both had a stronger correlation at 60 minutes (salivary cortisol r = .89, P < .001, salivary cortisone r = .85, P < .001). The relationship was examined excluding samples in the dynamic phase (baseline to 60 minutes). Salivary cortisol and cortisone showed a close relationship to serum cortisol. Salivary cortisone showed the stronger correlation salivary cortisol r = .82, P < .001, salivary cortisone r = .96, P < .001.CONCLUSION:
Following synacthen, both salivary cortisol and cortisone reflect serum cortisol levels, but there is a lag in their rise up to 60 minutes. The results support further research for possible future use of a 60-minute salivary cortisone measurement during the synacthen test.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Cortisona
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Hidrocortisona
Tipo de estudo:
Observational_studies
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article