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Reduced state transition barrier of CDK6 from open to closed state induced by Thr177 phosphorylation and its implication in binding modes of inhibitors.
He, Huan; Xu, Juan; Xie, Wen; Guo, Qing-Lian; Jiang, Feng-Lei; Liu, Yi.
Afiliação
  • He H; State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) & Key Laboratory of Biomedical Polymer Materials (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
  • Xu J; State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) & Key Laboratory of Biomedical Polymer Materials (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
  • Xie W; Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China.
  • Guo QL; Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan 430071, PR China.
  • Jiang FL; State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) & Key Laboratory of Biomedical Polymer Materials (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China. Electronic address: fljiang@whu.edu.cn.
  • Liu Y; State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) & Key Laboratory of Biomedical Polymer Materials (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China; Key Laboratory of Coal Conversion and Carbon
Biochim Biophys Acta Gen Subj ; 1862(3): 501-512, 2018 Mar.
Article em En | MEDLINE | ID: mdl-29108955
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotreonina / Processamento de Proteína Pós-Traducional / Inibidores de Proteínas Quinases / Quinase 6 Dependente de Ciclina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotreonina / Processamento de Proteína Pós-Traducional / Inibidores de Proteínas Quinases / Quinase 6 Dependente de Ciclina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article