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The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists.
Huang, Xianhai; Rao, Ashwin; Zhou, Wei; Aslanian, Robert; Nargund, Ravi; Buevich, Alexei; Zhang, Li-Kang; Qiu, Hongchen; Yang, Xiaoxin; Garlisi, Charles G; Correll, Craig; Palani, Anandan.
Afiliação
  • Huang X; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: xianhai.huang@merck.com.
  • Rao A; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Zhou W; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Aslanian R; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Nargund R; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Buevich A; Process Research and Development, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Zhang LK; Process Research and Development, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Qiu H; In Vitro Pharmacology, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Yang X; In Vitro Pharmacology, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Garlisi CG; In Vitro Pharmacology, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Correll C; Immunology, MRL, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Palani A; Discovery Chemistry, MRL, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett ; 27(23): 5344-5348, 2017 12 01.
Article em En | MEDLINE | ID: mdl-29110986
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Prostaglandina / Receptores Imunológicos / Isoquinolinas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Prostaglandina / Receptores Imunológicos / Isoquinolinas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article