PIM activity in tumours: A key node of therapy resistance.
Adv Biol Regul
; 67: 163-169, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29111105
ABSTRACT
The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Resistencia a Medicamentos Antineoplásicos
/
Proteínas Proto-Oncogênicas c-pim-1
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article