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NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.
Malhotra, Sunny; Sorosina, Melissa; Río, Jordi; Peroni, Silvia; Midaglia, Luciana; Villar, Luisa M; Álvarez-Cermeño, José C; Schroeder, Ina; Esposito, Federica; Clarelli, Ferdinando; Zettl, Uwe K; Lechner-Scott, Jeannette; Spataro, Nino; Navarro, Arcadi; Comi, Giancarlo; Montalban, Xavier; Martinelli-Boneschi, Filippo; Comabella, Manuel.
Afiliação
  • Malhotra S; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Sorosina M; Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
  • Río J; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Peroni S; Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
  • Midaglia L; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Villar LM; Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid, Spain.
  • Álvarez-Cermeño JC; Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid, Spain.
  • Schroeder I; Department of Neurology, Neuroimmunological Section, University of Rostock, Rostock, Germany.
  • Esposito F; Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy/Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Insti
  • Clarelli F; Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
  • Zettl UK; Department of Neurology, Neuroimmunological Section, University of Rostock, Rostock, Germany.
  • Lechner-Scott J; Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia/Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.
  • Spataro N; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain/Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Navarro A; National Institute for Bioinformatics, Universitat Pompeu Fabra, Barcelona, Spain/Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
  • Comi G; Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
  • Montalban X; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Martinelli-Boneschi F; Laboratory of Genetics of Complex Disorders and Department of Neurology, IRCCS Policlinico San Donato, Milan, Italy/Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
  • Comabella M; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Mult Scler ; 24(11): 1507-1510, 2018 10.
Article em En | MEDLINE | ID: mdl-29117789
ABSTRACT
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNß) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNß treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNß and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNß in MS patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon beta / Proteína 3 que Contém Domínio de Pirina da Família NLR / Fatores Imunológicos / Esclerose Múltipla Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon beta / Proteína 3 que Contém Domínio de Pirina da Família NLR / Fatores Imunológicos / Esclerose Múltipla Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article