Improvement in the Thermostability of a ß-Amino Acid Converting &#969;-Transaminase by Using FoldX.

Buß, Oliver; Muller, Delphine; Jager, Sven; Rudat, Jens; Rabe, Kersten S

Improvement in the Thermostability of a ß-Amino Acid Converting ω-Transaminase by Using FoldX.

Buß, Oliver; Muller, Delphine; Jager, Sven; Rudat, Jens; Rabe, Kersten S.

Afiliação

Buß O; Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 3, 76131, Karlsruhe, Germany.
Muller D; Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 3, 76131, Karlsruhe, Germany.
Jager S; Computational Biology, Technische Universität Darmstadt, Schnittspahnstrasse 2, 64287, Darmstadt, Germany.
Rudat J; Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 3, 76131, Karlsruhe, Germany.
Rabe KS; Institute for Biological Interfaces I, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

Chembiochem ; 19(4): 379-387, 2018 02 16.

Article em En | MEDLINE | ID: mdl-29120530

Assuntos

Aminoácidos/metabolismo; Comamonadaceae/enzimologia; Software; Transaminases/metabolismo; Temperatura de Transição; Aminoácidos/química; Biotransformação; Estabilidade Enzimática; Mutagênese Sítio-Dirigida; Transaminases/química; Transaminases/genética

Palavras-chave

amino acids; biocatalysis; enzyme engineering; thermostability; transaminases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Comamonadaceae / Temperatura de Transição / Aminoácidos / Transaminases Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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