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Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure-Activity Relationships.
Satake, Masayuki; Cornelio, Kimberly; Hanashima, Shinya; Malabed, Raymond; Murata, Michio; Matsumori, Nobuaki; Zhang, Huiping; Hayashi, Fumiaki; Mori, Shoko; Kim, Jong Souk; Kim, Chang-Hoon; Lee, Jong-Soo.
Afiliação
  • Satake M; Department of Chemistry, School of Science, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Cornelio K; Department of Chemistry, Graduate School of Science, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Hanashima S; JST ERATO Lipid Active Structure Project , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Malabed R; Department of Chemistry, Graduate School of Science, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Murata M; Department of Chemistry, Graduate School of Science, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Matsumori N; Department of Chemistry, Graduate School of Science, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Zhang H; JST ERATO Lipid Active Structure Project , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
  • Hayashi F; Department of Chemistry, Graduate School of Sciences, Kyushu University , 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
  • Mori S; RIKEN Center for Life Science Technology , 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
  • Kim JS; RIKEN Center for Life Science Technology , 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
  • Kim CH; Bioorganic Research Institute, Suntory Foundation for Life Sciences , Sikadai, Seika-cho, Soraku-gun, Kyoto 619-0284 Japan.
  • Lee JS; Department of Marine Bio-materials & Aquaculture, Pukyong National University , Busan 608-737, Korea.
J Nat Prod ; 80(11): 2883-2888, 2017 11 22.
Article em En | MEDLINE | ID: mdl-29120640
ABSTRACT
Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homologues, amphidinols 20 (AM20, 1) and 21 (AM21, 2), were isolated from Amphidinium carterae collected in Korea. Their structures were elucidated by detailed NMR analyses as amphidinol 6-type compounds with remarkably long polyol chains. Amphidinol 21 (2) has the longest linear structure among the amphidinol homologues reported so far. The congeners, particularly amphidinol 21 (2), showed weaker activity in hemolysis and antifungal assays compared to known amphidinols.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dinoflagellida / Medicamentos de Ervas Chinesas / Policetídeos Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dinoflagellida / Medicamentos de Ervas Chinesas / Policetídeos Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article