Influence of chemical denaturants on the activity, fold and zinc status of anthrax lethal factor.

Lo, Suet Y; Säbel, Crystal E; Mapletoft, Jonathan P J; Siemann, Stefan

Lo, Suet Y; Säbel, Crystal E; Mapletoft, Jonathan P J; Siemann, Stefan.

Afiliação

Lo SY; Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada.
Säbel CE; Bharti School of Engineering, Laurentian University, Sudbury, Ontario, Canada.
Mapletoft JPJ; Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada.
Siemann S; Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada.

Biochem Biophys Rep ; 1: 68-77, 2015 May.

Article em En | MEDLINE | ID: mdl-29124135

Palavras-chave

4-(2-pyridylazo)resorcinol; CD, circular dichroism; Chemical denaturants; DPA, dipicolinic acid; EDTA, ethylenediaminetetraacetic acid; EF, edema factor; LF, anthrax lethal factor; Lethal factor; MWCO, molecular weight cut-off; PA, protective antigen; PAR, 4-(2-pyridylazo)resorcinol; Protein folding; S-pNA, lethal factor substrate; SASA, solvent-accessible surface area; SOD, superoxide dismutase; Tryptophan fluorescence; Zinc; ZnLF, zinc-containing lethal factor; cps, counts per second

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article