Your browser doesn't support javascript.
loading
miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.
Chou, Chih-Hung; Shrestha, Sirjana; Yang, Chi-Dung; Chang, Nai-Wen; Lin, Yu-Ling; Liao, Kuang-Wen; Huang, Wei-Chi; Sun, Ting-Hsuan; Tu, Siang-Jyun; Lee, Wei-Hsiang; Chiew, Men-Yee; Tai, Chun-San; Wei, Ting-Yen; Tsai, Tzi-Ren; Huang, Hsin-Tzu; Wang, Chung-Yu; Wu, Hsin-Yi; Ho, Shu-Yi; Chen, Pin-Rong; Chuang, Cheng-Hsun; Hsieh, Pei-Jung; Wu, Yi-Shin; Chen, Wen-Liang; Li, Meng-Ju; Wu, Yu-Chun; Huang, Xin-Yi; Ng, Fung Ling; Buddhakosai, Waradee; Huang, Pei-Chun; Lan, Kuan-Chun; Huang, Chia-Yen; Weng, Shun-Long; Cheng, Yeong-Nan; Liang, Chao; Hsu, Wen-Lian; Huang, Hsien-Da.
Afiliação
  • Chou CH; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Shrestha S; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Yang CD; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Chang NW; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Lin YL; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, 350, Taiwan.
  • Liao KW; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 106, Taiwan.
  • Huang WC; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Sun TH; Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Tu SJ; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Lee WH; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Chiew MY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Tai CS; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Wei TY; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Tsai TR; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Huang HT; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Wang CY; Clinical Research Center, Chung Shan Medical University Hospital, Taichung, 402, Taiwan.
  • Wu HY; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Ho SY; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Chen PR; Interdisciplinary Program of Life Science, National Tsing Hua University, Hsinchu, 300, Taiwan.
  • Chuang CH; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Hsieh PJ; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Wu YS; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Chen WL; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Li MJ; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Wu YC; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Huang XY; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Ng FL; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Buddhakosai W; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Huang PC; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Lan KC; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Huang CY; Department of Pediatrics, National Taiwan University Hospital Hsinchu Branch, Hsinchu, 300, Taiwan.
  • Weng SL; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Cheng YN; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Liang C; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Hsu WL; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan.
  • Huang HD; Delivery Room, Department of Nursing, National Taiwan University Hospital Hsinchu Branch, Hsinchu, 300, Taiwan.
Nucleic Acids Res ; 46(D1): D296-D302, 2018 01 04.
Article em En | MEDLINE | ID: mdl-29126174
ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ∼1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http//miRTarBase.mbc.nctu.edu.tw/.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Bases de Dados Genéticas / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Bases de Dados Genéticas / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article