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YRNA expression predicts survival in bladder cancer patients.
Tolkach, Yuri; Stahl, Anna Franziska; Niehoff, Eva-Maria; Zhao, Chenming; Kristiansen, Glen; Müller, Stefan Cajetan; Ellinger, Jörg.
Afiliação
  • Tolkach Y; Institute of Pathology, University Hospital Bonn, Bonn, Germany.
  • Stahl AF; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Niehoff EM; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Zhao C; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Kristiansen G; Institute of Pathology, University Hospital Bonn, Bonn, Germany.
  • Müller SC; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Ellinger J; Department of Urology, University Hospital Bonn, Bonn, Germany. joerg.ellinger@ukbonn.de.
BMC Cancer ; 17(1): 749, 2017 Nov 10.
Article em En | MEDLINE | ID: mdl-29126388
BACKGROUND: Non-coding RNAs play an important role in human carcinogenesis. YRNAs (Ro-associated Y), a novel class of non-coding RNAs, have been identified as biomarker in various malignancies, but remain to be studied in urinary bladder cancer (BCA) patients. METHODS: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival BCA (urothelial carcinoma, n = 88) and normal urothelial bladder (n = 30) tissues using quantitative real-time PCR. Associations with clinicopathological parameters and prognostic role for overall and cancer-specific survival were analysed. RESULTS: All YRNAs were significantly downregulated in BCA tissue. A low expression of RNY1, RNY3 and RNY4 was associated with muscle-invasive BCA, lymph node metastases and advanced grade. Furthermore, expression of RNY1 and RNY3 was predictive for BCA patients' overall (also RNY4) and cancer-specific survival as estimated using Kaplan-Meier and univariate (but not multivariate) Cox regression analyses. RNY1, RNY3 and RNY4 show good discriminative ability between tumor and normal tissue, as well as between muscle-invasive and non-muscle-invasive urothelial carcinoma. CONCLUSIONS: The expression of YRNAs is altered in BCA and associated with poor prognosis. Possible diagnostic role of YRNAs should be investigated in further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Autoantígenos / Neoplasias da Bexiga Urinária / Biomarcadores Tumorais / RNA Citoplasmático Pequeno / Metástase Linfática Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Autoantígenos / Neoplasias da Bexiga Urinária / Biomarcadores Tumorais / RNA Citoplasmático Pequeno / Metástase Linfática Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article