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IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft.
Martins-Neves, Sara R; Paiva-Oliveira, Daniela I; Fontes-Ribeiro, Carlos; Bovée, Judith V M G; Cleton-Jansen, Anne-Marie; Gomes, Célia M F.
Afiliação
  • Martins-Neves SR; Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; CIMAGO, University of Coimbra, Coimbra, Portugal; Department of Pathology, Leiden Universit
  • Paiva-Oliveira DI; Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal.
  • Fontes-Ribeiro C; Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal.
  • Bovée JVMG; Department of Pathology, Leiden University Medical Center, P.O.Box 9600, L1-Q, 2300 RC, Leiden, The Netherlands.
  • Cleton-Jansen AM; Department of Pathology, Leiden University Medical Center, P.O.Box 9600, L1-Q, 2300 RC, Leiden, The Netherlands.
  • Gomes CMF; Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; CIMAGO, University of Coimbra, Coimbra, Portugal. Electronic address: cgomes@fmed.uc.pt.
Cancer Lett ; 414: 1-15, 2018 02 01.
Article em En | MEDLINE | ID: mdl-29126913
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Células-Tronco Neoplásicas / Osteossarcoma / Ensaios Antitumorais Modelo de Xenoenxerto / Tanquirases / Via de Sinalização Wnt / Imidas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Células-Tronco Neoplásicas / Osteossarcoma / Ensaios Antitumorais Modelo de Xenoenxerto / Tanquirases / Via de Sinalização Wnt / Imidas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article