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Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.
Fan, Ying; Howden, Andrew J M; Sarhan, Adil R; Lis, Pawel; Ito, Genta; Martinez, Terina N; Brockmann, Kathrin; Gasser, Thomas; Alessi, Dario R; Sammler, Esther M.
Afiliação
  • Fan Y; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Howden AJM; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, U.K.
  • Sarhan AR; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Lis P; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Ito G; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Martinez TN; The Michael J. Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A.
  • Brockmann K; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen 72076, Germany.
  • Gasser T; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.
  • Alessi DR; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen 72076, Germany.
  • Sammler EM; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.
Biochem J ; 475(1): 23-44, 2018 01 02.
Article em En | MEDLINE | ID: mdl-29127255
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas rab de Ligação ao GTP / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Mutação / Neutrófilos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas rab de Ligação ao GTP / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Mutação / Neutrófilos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article