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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Huang, Hai-Tsang; Dobrovolsky, Dennis; Paulk, Joshiawa; Yang, Guang; Weisberg, Ellen L; Doctor, Zainab M; Buckley, Dennis L; Cho, Joong-Heui; Ko, Eunhwa; Jang, Jaebong; Shi, Kun; Choi, Hwan Geun; Griffin, James D; Li, Ying; Treon, Steven P; Fischer, Eric S; Bradner, James E; Tan, Li; Gray, Nathanael S.
Afiliação
  • Huang HT; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Dobrovolsky D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Paulk J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Yang G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Weisberg EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Doctor ZM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Buckley DL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Cho JH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
  • Ko E; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
  • Jang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Shi K; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Choi HG; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
  • Griffin JD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Li Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
  • Treon SP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Bradner JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Tan L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chines
  • Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: nathanael_gray@dfci.harvard.edu.
Cell Chem Biol ; 25(1): 88-99.e6, 2018 01 18.
Article em En | MEDLINE | ID: mdl-29129717
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteômica / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Tirosina Quinase da Agamaglobulinemia Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteômica / Inibidores de Proteínas Quinases / Tirosina Quinase 3 Semelhante a fms / Tirosina Quinase da Agamaglobulinemia Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article