Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.

Bansal, Megha; Moharir, Shivranjani C; Sailasree, S Purnima; Sirohi, Kapil; Sudhakar, Cherukuri; Sarathi, D Partha; Lakshmi, B Jyothi; Buono, Mario; Kumar, Satish; Swarup, Ghanshyam

Bansal, Megha; Moharir, Shivranjani C; Sailasree, S Purnima; Sirohi, Kapil; Sudhakar, Cherukuri; Sarathi, D Partha; Lakshmi, B Jyothi; Buono, Mario; Kumar, Satish; Swarup, Ghanshyam.

Afiliação

Bansal M; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Moharir SC; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Sailasree SP; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Sirohi K; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Sudhakar C; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Sarathi DP; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Lakshmi BJ; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Buono M; MRC Molecular Hematology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom.
Kumar S; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Swarup G; Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology, Hyderabad-500007, India. Electronic address: gshyam@ccmb.res.in.

J Biol Chem ; 293(1): 132-147, 2018 01 05.

Article em En | MEDLINE | ID: mdl-29133525

Assuntos

Proteínas Relacionadas à Autofagia/metabolismo; Proteínas de Transporte/metabolismo; Proteínas do Olho/metabolismo; Proteínas de Membrana/metabolismo; Fator de Transcrição TFIIIA/metabolismo; Animais; Autofagossomos/metabolismo; Autofagia/fisiologia; Proteínas de Ciclo Celular; Feminino; Células HEK293; Humanos; Masculino; Proteínas de Membrana Transportadoras; Camundongos; Camundongos Knockout; Proteínas Associadas aos Microtúbulos/metabolismo; Proteínas de Ligação a Fosfato; Ligação Proteica

Palavras-chave

AMP-activated kinase (AMPK); Atg12-5-16L1; Wipi2; autophagosome formation; autophagy; mutant; optineurin; phagophore maturation; phosphorylation; ubiquitin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Fator de Transcrição TFIIIA / Proteínas do Olho / Proteínas Relacionadas à Autofagia / Proteínas de Membrana Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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