Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.

Chitsazan, Arash; Ferguson, Blake; Villani, Rehan; Handoko, Herlina Y; Mukhopadhyay, Pamela; Gabrielli, Brian; Mooi, Wolter J; Soyer, H Peter; Lambie, Duncan; Khosrotehrani, Kiarash; Morahan, Grant; Walker, Graeme J

Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.

Chitsazan, Arash; Ferguson, Blake; Villani, Rehan; Handoko, Herlina Y; Mukhopadhyay, Pamela; Gabrielli, Brian; Mooi, Wolter J; Soyer, H Peter; Lambie, Duncan; Khosrotehrani, Kiarash; Morahan, Grant; Walker, Graeme J.

Afiliação

Chitsazan A; Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Ferguson B; Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Villani R; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Handoko HY; Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Mukhopadhyay P; Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Gabrielli B; Mater Medical Research Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Mooi WJ; Department of Pathology, Vrije University Medical Center, Amsterdam, the Netherlands.
Soyer HP; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Lambie D; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Khosrotehrani K; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Morahan G; Centre for Diabetes Research, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia.
Walker GJ; Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address: Graeme.Walker@qimrberghofer.edu.au.

J Invest Dermatol ; 138(4): 893-902, 2018 04.

Article em En | MEDLINE | ID: mdl-29138054

Assuntos

Endotelina-1/metabolismo; Regulação Neoplásica da Expressão Gênica; Proteínas Hedgehog/genética; Queratinócitos/metabolismo; Neoplasias Experimentais; Nevo Pigmentado/genética; Neoplasias Cutâneas/genética; Regulação para Cima; Animais; Feminino; Proteínas Hedgehog/biossíntese; Humanos; Queratinócitos/patologia; Masculino; Melanócitos/metabolismo; Melanócitos/patologia; Camundongos; Camundongos Knockout; Nevo Pigmentado/metabolismo; Nevo Pigmentado/patologia; Transdução de Sinais; Neoplasias Cutâneas/metabolismo; Neoplasias Cutâneas/patologia; Ativação Transcricional; Células Tumorais Cultivadas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Regulação Neoplásica da Expressão Gênica / Queratinócitos / Regulação para Cima / Endotelina-1 / Proteínas Hedgehog / Neoplasias Experimentais / Nevo Pigmentado Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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