Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.
J Nat Prod
; 80(12): 3103-3111, 2017 12 22.
Article
em En
| MEDLINE
| ID: mdl-29140705
ABSTRACT
Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 µM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Cornus
/
Iridoides
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Glucosídeos Iridoides
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Frutas
/
Glucosídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article