Association of XPG gene rs751402 polymorphism with gastric cancer risk: a meta-analysis in the Chinese population.
Int J Biol Markers
; 33(2): 174-179, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29148016
ABSTRACT
BACKGROUND:
Previous studies have revealed a conflicting relationship of xeroderma pigmentosum group G (XPG) gene polymorphism with gastric cancer (GC) risk. To our knowledge, this is the first meta-analysis to investigate the association between rs751402 mutation located on the XPG promoter region and GC risk.METHODS:
We undertook a meta-analysis by identifying relevant articles from the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) databases on February 28, 2017. By pooling 9 eligible studies, 3,539 GC cases and 3,948 controls were included. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using the fixed-effects or random-effects model depending on the existence of heterogeneity across studies. The population attributable risk (PAR%) was estimated to better understand the public health risk.RESULTS:
All included studies had been conducted in China. Significant associations were found between the XPG rs751402 polymorphism and the risk of GC (TT vs. CC OR = 1.43, 95% CI, 1.11-1.84; CT vs. CC OR = 1.15, 95% CI, 1.04-1.26; dominant model OR = 1.17, 95% CI, 1.07-1.29; recessive model OR = 1.30, 95% CI, 1.05-1.62; T vs. C OR = 1.18, 95% CI, 1.06-1.32). The estimated PAR% was about 4.9%-8.8%. Funnel plots did not reveal any potential publication bias. The sensitivity analyses showed that the results were relatively robust.CONCLUSIONS:
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Fatores de Transcrição
/
Proteínas Nucleares
/
Predisposição Genética para Doença
/
Proteínas de Ligação a DNA
/
Endonucleases
/
Estudos de Associação Genética
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article