High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases.

Ricciotti, Robert W; Baraff, Aaron J; Jour, George; Kyriss, McKenna; Wu, Yu; Liu, Yuhua; Li, Shao-Chun; Hoch, Benjamin; Liu, Yajuan J

Ricciotti, Robert W; Baraff, Aaron J; Jour, George; Kyriss, McKenna; Wu, Yu; Liu, Yuhua; Li, Shao-Chun; Hoch, Benjamin; Liu, Yajuan J.

Afiliação

Ricciotti RW; Department of Pathology, University of Washington School of Medicine, Seattle, WA.
Baraff AJ; Department of BioStatistics, University of Washington School of Medicine, Seattle, WA.
Jour G; Department of Pathology and Laboratory Medicine, MD Anderson Cancer Center at Cooper, Camden, NJ.
Kyriss M; Prevention Genetics, Marshfield, WI.
Wu Y; Department of Pathology, University of Washington School of Medicine, Seattle, WA.
Liu Y; Department of Pathology, University of Washington School of Medicine, Seattle, WA.
Li SC; Department of Pharmacology, School of Medicine, Hebei University, PR China.
Hoch B; Department of Pathology, University of Washington School of Medicine, Seattle, WA. Electronic address: bhoch@u.washington.edu.
Liu YJ; Department of Pathology, University of Washington School of Medicine, Seattle, WA. Electronic address: yajuan@uw.edu.

Cancer Genet ; 218-219: 69-80, 2017 Dec.

Article em En | MEDLINE | ID: mdl-29153098

Assuntos

Biomarcadores Tumorais/genética; Diferenciação Celular; Quinase 4 Dependente de Ciclina/genética; Amplificação de Genes; Lipossarcoma/patologia; Proteínas Proto-Oncogênicas c-mdm2/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Feminino; Seguimentos; Dosagem de Genes; Humanos; Hibridização in Situ Fluorescente; Lipossarcoma/genética; Masculino; Análise em Microsséries; Pessoa de Meia-Idade; Estadiamento de Neoplasias; Prognóstico; Estudos Retrospectivos

Palavras-chave

CDK amplification; CMA; DDLS; Dedifferentiated liposarcoma; MDM2 amplification; cytogenomic microarray analysis; prognosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Diferenciação Celular / Amplificação de Genes / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 4 Dependente de Ciclina / Lipossarcoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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