MicroRNA-30a-3p is overexpressed in the placentas of patients with preeclampsia and affects trophoblast invasion and apoptosis by its effects on IGF-1.

Niu, Zi-Ru; Han, Tao; Sun, Xiao-Luan; Luan, Li-Xia; Gou, Wen-Li; Zhu, Xiao-Ming

Niu, Zi-Ru; Han, Tao; Sun, Xiao-Luan; Luan, Li-Xia; Gou, Wen-Li; Zhu, Xiao-Ming.

Afiliação

Niu ZR; Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China; Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong, China.
Han T; Department of Orthopedics, Hainan Branch of PLA General Hospital, Sanya, China.
Sun XL; Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Luan LX; Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Gou WL; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zhu XM; Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: xiaomingzhu1981@hotmail.com.

Am J Obstet Gynecol ; 218(2): 249.e1-249.e12, 2018 02.

Article em En | MEDLINE | ID: mdl-29155142

Assuntos

Regulação da Expressão Gênica no Desenvolvimento; Fator de Crescimento Insulin-Like I/metabolismo; MicroRNAs/metabolismo; Placenta/metabolismo; Pré-Eclâmpsia/genética; Trofoblastos/fisiologia; Adulto; Apoptose/genética; Biomarcadores/metabolismo; Western Blotting; Estudos de Casos e Controles; Células Cultivadas; Epigênese Genética; Feminino; Humanos; Pré-Eclâmpsia/metabolismo; Gravidez; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Regulação para Cima

Palavras-chave

IGF-1; apoptosis; epigenetics; functional assays; invasion; microRNA; placenta; preeclampsia; trophoblast

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Placenta / Pré-Eclâmpsia / Trofoblastos / Fator de Crescimento Insulin-Like I / Regulação da Expressão Gênica no Desenvolvimento / MicroRNAs Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google