Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women.
Brain Behav Immun
; 69: 203-209, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29157934
ABSTRACT
BACKGROUND:
Research has linked posttraumatic stress disorder (PTSD) with higher circulating levels of inflammatory and endothelial function (EF) biomarkers, and effects may be bidirectional. We conducted the first investigation of new-onset PTSD and changes in inflammatory and EF biomarkers.METHODS:
Data were from women in the Nurses' Health Study II. Biomarkers obtained at two blood draws, 10-16â¯years apart, included C-reactive protein (CRP), tumor necrosis factor-alpha receptor-II (TNFRII), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1). PTSD was assessed via interview. Analyses compared biomarker levels in women with PTSD that onset between draws (nâ¯=â¯175) to women with no history of trauma (nâ¯=â¯175) and to women with history of trauma at draw 1 and no PTSD at either draw (nâ¯=â¯175). We examined if PTSD onset was associated with biomarker change over time and if pre-PTSD-onset biomarker levels indicated risk of subsequent PTSD using linear mixed models and linear regression, respectively. Biomarkers were log-transformed.RESULTS:
Compared to women without trauma, women in the PTSD onset group had larger increases in VCAM-1 over time (bâ¯=â¯0.003, pâ¯=â¯.068). They also had higher TNFRII (bâ¯=â¯0.05, pâ¯=â¯.049) and ICAM-1 (bâ¯=â¯0.04, pâ¯=â¯.060) levels at draw 1 (prior to trauma and PTSD onset). However, pre-PTSD-onset biomarker levels did not predict onset of more severe PTSD.CONCLUSIONS:
PTSD onset (vs. no trauma) was associated with increases in one inflammation-related biomarker. Effects may be small and cumulative; longer follow-up periods with larger samples are needed. We did not observe strong support that pre-PTSD-onset biomarkers predicted risk of subsequent PTSD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
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Proteína C-Reativa
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Molécula 1 de Adesão Intercelular
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Molécula 1 de Adesão de Célula Vascular
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Receptores Tipo II do Fator de Necrose Tumoral
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Inflamação
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article