Advanced Strategies for Eliminating the cccDNA of HBV.
Dig Dis Sci
; 63(1): 7-15, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29159681
ABSTRACT
Persistent hepatitis B virus (HBV) infection of hepatocytes is associated with a covalently closed circular DNA (cccDNA) episome. Although serologic hepatitis B surface antigen tests are negative, the presence of cccDNA is obviously increased in HBeAg-positive patients compared with that in HBeAg-negative patients, inactive carriers and patients. Moreover, trace cccDNA levels can also be found in the liver cells of patients with resolved hepatitis B infections. Therefore, clearance of cccDNA in hepatocytes could be an effective cure for HBV. In this review, we summarize the strategies that have been employed to eliminate cccDNA in recent years and discuss the future development of treatments for chronic hepatitis B.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Circular
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Vírus da Hepatite B
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Interferência de RNA
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Edição de Genes
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Hepatite B
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article