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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.
Bowsher, Michael; Hiebert, Sheldon; Li, Rongti; Wang, Alan X; Friborg, Jacques; Yu, Fei; Hernandez, Dennis; Wang, Ying-Kai; Klei, Herbert; Rajamani, Ramkumar; Mosure, Kathy; Knipe, Jay O; Meanwell, Nicholas A; McPhee, Fiona; Scola, Paul M.
Afiliação
  • Bowsher M; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: michael.bowsher@bms.com.
  • Hiebert S; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Li R; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Wang AX; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Friborg J; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Yu F; Bristol-Myers Squibb, Research and Development, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA.
  • Hernandez D; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Wang YK; Bristol-Myers Squibb, Research and Development, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA.
  • Klei H; Bristol-Myers Squibb, Research and Development, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA.
  • Rajamani R; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Mosure K; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Knipe JO; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Meanwell NA; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • McPhee F; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Scola PM; Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorg Med Chem Lett ; 28(1): 43-48, 2018 01 01.
Article em En | MEDLINE | ID: mdl-29162454
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Proteínas não Estruturais Virais / Compostos Macrocíclicos / Naftalenos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Proteínas não Estruturais Virais / Compostos Macrocíclicos / Naftalenos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article