Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domain Synthesized in E. coli: In Vivo Osteoinductivity in Experimental Models on Small and Large Laboratory Animals.
Bull Exp Biol Med
; 164(2): 148-151, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29177907
Recombinant human bone morphogenetic protein-2 with an additional s-tag domain (s-tag-BMP-2) synthesized in E. coli is characterized by higher solubility and activity than the protein without additional s-tag domain, which increases the yield during purification and simplifies protein introduction into the osteoplastic materials. The high osteoinductivity of the demineralized bone matrix with s-tag-BMP-2 was shown on the model of regeneration of cranial defects of a critical size in mice and on the model of implantation of porous titanium matrix into defects of femoral and tibial bones in rabbits.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Crânio
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Tíbia
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Regeneração Óssea
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Proteínas Recombinantes de Fusão
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Proteína Morfogenética Óssea 2
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Fêmur
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article