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Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations.
Moorthy, Balakrishnan S; Zarraga, Isidro E; Kumar, Lokesh; Walters, Benjamin T; Goldbach, Pierre; Topp, Elizabeth M; Allmendinger, Andrea.
Afiliação
  • Moorthy BS; Department of Industrial and Physical Pharmacy, Purdue University , West Lafayette, Indiana 47907, United States.
  • Zarraga IE; Late State Pharmaceutical Development, Genentech (A Member of the Roche Group) , South San Francisco, California 94080, United States.
  • Kumar L; Pharmaceutical Processing and Technology Development, Genentech (A Member of the Roche Group) , South San Francisco, California 94080, United States.
  • Walters BT; Early State Pharmaceutical Development, Genentech (A Member of the Roche Group) , South San Francisco, California 94080, United States.
  • Goldbach P; Late-stage Pharmaceutical and Processing Development, Pharmaceutical Development and Supplies, Biologics, Europe, Hoffmann-La Roche , CH-4070 Basel, Switzerland.
  • Topp EM; Department of Industrial and Physical Pharmacy, Purdue University , West Lafayette, Indiana 47907, United States.
  • Allmendinger A; Late-stage Pharmaceutical and Processing Development, Pharmaceutical Development and Supplies, Biologics, Europe, Hoffmann-La Roche , CH-4070 Basel, Switzerland.
Mol Pharm ; 15(1): 1-11, 2018 01 02.
Article em En | MEDLINE | ID: mdl-29182876
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Medição da Troca de Deutério / Liofilização / Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Medição da Troca de Deutério / Liofilização / Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article