A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

Dobes, Jan; Edenhofer, Frank; Voboril, Matous; Brabec, Tomás; Dobesová, Martina; Cepková, Adéla; Klein, Ludger; Rajewsky, Klaus; Filipp, Dominik

Dobes, Jan; Edenhofer, Frank; Voboril, Matous; Brabec, Tomás; Dobesová, Martina; Cepková, Adéla; Klein, Ludger; Rajewsky, Klaus; Filipp, Dominik.

Afiliação

Dobes J; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Edenhofer F; Institute of Genetics, University of Cologne, Cologne, Germany.
Voboril M; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Brabec T; Department of Cell biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Dobesová M; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Cepková A; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Klein L; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Rajewsky K; Laboratory of Thymusfuction, Institute for Immunology, Ludwig-Maxmilians-Universität München, Munich, Germany.
Filipp D; Institute of Genetics, University of Cologne, Cologne, Germany.

Eur J Immunol ; 48(3): 546-548, 2018 03.

Article em En | MEDLINE | ID: mdl-29193031

ABSTRACT

ABSTRACT

Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Airefl/fl mouse strain enables the investigation of the cell-specific function of Aire.

Assuntos

Tolerância Imunológica/genética; Poliendocrinopatias Autoimunes/genética; Poliendocrinopatias Autoimunes/imunologia; Fatores de Transcrição/genética; Fatores de Transcrição/imunologia; Animais; Células Apresentadoras de Antígenos/patologia; Linhagem da Célula/genética; Linhagem da Célula/imunologia; Feminino; Humanos; Masculino; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Poliendocrinopatias Autoimunes/patologia; Reprodução/genética; Reprodução/imunologia; Proteína AIRE

Palavras-chave

Aire; Conditional knockout; Immune tolerance; Medullary thymic epithelial cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Poliendocrinopatias Autoimunes / Tolerância Imunológica Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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