Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia-reperfusion injury by strengthening the blood-brain barrier function and anti-thrombo-inflammatory property.

Chen, Chunyan; Li, Tingting; Zhao, Yuchen; Qian, Yinfeng; Li, Xiaoyi; Dai, Xiangrong; Huang, Dake; Pan, Tianzhong; Zhou, Lanlan

Chen, Chunyan; Li, Tingting; Zhao, Yuchen; Qian, Yinfeng; Li, Xiaoyi; Dai, Xiangrong; Huang, Dake; Pan, Tianzhong; Zhou, Lanlan.

Afiliação

Chen C; Department of Pharmacology, School of Basic Medical Science, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China.
Li T; Department of Pharmacology, School of Basic Medical Science, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China; Department of Pharmacy, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230032, PR China
Zhao Y; Department of Pharmacology, School of Basic Medical Science, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China.
Qian Y; Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, PR China.
Li X; Zhaoke Pharmaceutical Co. Ltd, Hefei 230032, PR China.
Dai X; Zhaoke Pharmaceutical Co. Ltd, Hefei 230032, PR China.
Huang D; Synthetic Laboratory of Basic Medicine College, Anhui Medical University, Hefei 230032, PR China.
Pan T; Department of Pharmacology, School of Basic Medical Science, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China.
Zhou L; Department of Pharmacology, School of Basic Medical Science, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, PR China. Electronic address: zhoulanlan@ahmu.edu.cn.

Brain Behav Immun ; 69: 255-263, 2018 03.

Article em En | MEDLINE | ID: mdl-29195783

Assuntos

Barreira Hematoencefálica/efeitos dos fármacos; Venenos de Crotalídeos/uso terapêutico; Fibrinolíticos/uso terapêutico; Lectinas Tipo C/uso terapêutico; Complexo Glicoproteico GPIb-IX de Plaquetas/antagonistas & inibidores; Traumatismo por Reperfusão/tratamento farmacológico; Tirofibana/uso terapêutico; Animais; Barreira Hematoencefálica/metabolismo; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Venenos de Crotalídeos/farmacologia; Fibrinolíticos/farmacologia; Infarto da Artéria Cerebral Média/metabolismo; Masculino; Camundongos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Traumatismo por Reperfusão/metabolismo; Tirofibana/farmacologia

Palavras-chave

Blood-brain barrier; Macrophage-1 antigen; P-selectin; Platelet glycoprotein receptor Ib; Stroke; Thrombo-inflammation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Traumatismo por Reperfusão / Complexo Glicoproteico GPIb-IX de Plaquetas / Venenos de Crotalídeos / Lectinas Tipo C / Fibrinolíticos / Tirofibana Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google