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H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters.
Matsumura, Hiroya; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Tomomori, Shunsuke; Motoda, Chikaaki; Amioka, Michitaka; Hironobe, Naoya; Toshishige, Masaaki; Takahashi, Shinya; Imai, Katsuhiko; Sueda, Taijiro; Chayama, Kazuaki; Kihara, Yasuki.
Afiliação
  • Matsumura H; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Nakano Y; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. nakanoy@hiroshima-u.ac.jp.
  • Ochi H; Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan. nakanoy@hiroshima-u.ac.jp.
  • Onohara Y; Laboratory for Digestive Diseases, Center for Genomic Medicine, RIKEN, Hiroshima, Japan.
  • Sairaku A; Department of Gastroenterology and Metabolism, Division of Frontier Medical Science, Programs for Biomedical Research Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan.
  • Tokuyama T; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Tomomori S; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Motoda C; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Amioka M; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Hironobe N; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Toshishige M; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Takahashi S; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Imai K; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Sueda T; Department of Cardiovascular Surgery, Hiroshima University Hospital, Hiroshima, Japan.
  • Chayama K; Department of Cardiovascular Surgery, Hiroshima University Hospital, Hiroshima, Japan.
  • Kihara Y; Department of Cardiovascular Surgery, Hiroshima University Hospital, Hiroshima, Japan.
J Biomed Sci ; 24(1): 91, 2017 Dec 04.
Article em En | MEDLINE | ID: mdl-29202755
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Regiões Promotoras Genéticas / Polimorfismo de Nucleotídeo Único / Síndrome de Brugada / Canal de Sódio Disparado por Voltagem NAV1.5 Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Regiões Promotoras Genéticas / Polimorfismo de Nucleotídeo Único / Síndrome de Brugada / Canal de Sódio Disparado por Voltagem NAV1.5 Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article