Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine.
Clin Pharmacol Ther
; 45(3): 241-51, 1989 Mar.
Article
em En
| MEDLINE
| ID: mdl-2920499
ABSTRACT
Orthostatic hypotension, one of tricyclic antidepressant treatment's side effects, is also a factor in limiting adequate antidepressant dosing. We tested in a double-blind, crossover, placebo-controlled study the effect of low doses (4 mg/t.i.d.) of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension. Yohimbine, a selective alpha 2-adrenoceptor antagonist, had a favorable effect in orthostatic hypotension and induced a significant increase in blood pressure. A pharmacodynamic and pharmacokinetic interaction between yohimbine and clomipramine or demethylclomipramine was discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ioimbina
/
Pressão Sanguínea
/
Clomipramina
/
Depressão
/
Hipotensão Ortostática
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article