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The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.
Cardarelli, Ross A; Jones, Karen; Pisella, Lucie I; Wobst, Heike J; McWilliams, Lisa J; Sharpe, Paul M; Burnham, Matthew P; Baker, David J; Chudotvorova, Ilona; Guyot, Justine; Silayeva, Liliya; Morrow, Danielle H; Dekker, Niek; Zicha, Stephen; Davies, Paul A; Holenz, Jörg; Duggan, Mark E; Dunlop, John; Mather, Robert J; Wang, Qi; Medina, Igor; Brandon, Nicholas J; Deeb, Tarek Z; Moss, Stephen J.
Afiliação
  • Cardarelli RA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
  • Jones K; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
  • Pisella LI; INMED, INSERM, Unité 901, Marseille, France.
  • Wobst HJ; Aix-Marseille Université, UMR 901, Marseille, France.
  • McWilliams LJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
  • Sharpe PM; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Burnham MP; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Baker DJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
  • Chudotvorova I; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
  • Guyot J; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Silayeva L; INMED, INSERM, Unité 901, Marseille, France.
  • Morrow DH; Aix-Marseille Université, UMR 901, Marseille, France.
  • Dekker N; INMED, INSERM, Unité 901, Marseille, France.
  • Zicha S; Aix-Marseille Université, UMR 901, Marseille, France.
  • Davies PA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
  • Holenz J; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
  • Duggan ME; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
  • Dunlop J; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Mather RJ; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.
  • Wang Q; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Medina I; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Brandon NJ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Deeb TZ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Moss SJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
Nat Med ; 23(12): 1394-1396, 2017 12 07.
Article em En | MEDLINE | ID: mdl-29216042
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Simportadores / Tiazolidinas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Simportadores / Tiazolidinas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article