Oxymatrine Sensitizes the HaCaT Cells to the IFN-Î³ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt.

Gao, Chun-Jie; Ding, Pei-Jun; Yang, Li-Li; He, Xu-Feng; Chen, Meng-Jiao; Wang, Dong-Ming; Tian, Yan-Xin; Zhang, Hui-Min

Gao, Chun-Jie; Ding, Pei-Jun; Yang, Li-Li; He, Xu-Feng; Chen, Meng-Jiao; Wang, Dong-Ming; Tian, Yan-Xin; Zhang, Hui-Min.

Afiliação

Gao CJ; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ding PJ; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yang LL; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
He XF; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen MJ; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang DM; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tian YX; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhang HM; Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. happy2003_1@msn.com.

Inflammation ; 41(2): 606-613, 2018 Mar.

Article em En | MEDLINE | ID: mdl-29218605

Assuntos

Alcaloides/farmacologia; Quinolizinas/farmacologia; Dermatopatias/tratamento farmacológico; Linhagem Celular; Quimiocina CCL22; Regulação para Baixo/efeitos dos fármacos; Humanos; Imunossupressores; Molécula 1 de Adesão Intercelular; Interferon gama/metabolismo; Queratinócitos/citologia; Sistema de Sinalização das MAP Quinases; RNA Mensageiro/efeitos dos fármacos; Dermatopatias/imunologia; Proteína 1 Supressora da Sinalização de Citocina; Tacrolimo/farmacologia

Palavras-chave

IFN-Î³; MAPKs; SOCS1; allergic skin diseases; atopic dermatitis; oxymatrine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolizinas / Dermatopatias / Alcaloides Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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