An update on factor XI structure and function.
Thromb Res
; 161: 94-105, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29223926
ABSTRACT
Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic activation of several coagulation factors, most notably factor IX (FIX). FXI is a homolog of prekallikrein (PK), a component of the plasma kallikrein-kinin system. While sharing structural and functional features with PK, FXI has undergone adaptive changes that allow it to contribute to blood coagulation. Here we review current understanding of the biology and enzymology of FXI, with an emphasis on structural features of the protein as they relate to protease function.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator XI
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article