The in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS.

Liu, Xiuxiu; Tang, Minghai; Liu, Taohong; Wang, Chunyan; Tang, Qiaoxin; Xiao, Yaxin; Yang, Ruixin; Chao, Ruobing

Liu, Xiuxiu; Tang, Minghai; Liu, Taohong; Wang, Chunyan; Tang, Qiaoxin; Xiao, Yaxin; Yang, Ruixin; Chao, Ruobing.

Afiliação

Liu X; a West China School of Pharmacy, Sichuan University , Chengdu , China and.
Tang M; b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Liu T; a West China School of Pharmacy, Sichuan University , Chengdu , China and.
Wang C; b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Tang Q; b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu , China.
Xiao Y; a West China School of Pharmacy, Sichuan University , Chengdu , China and.
Yang R; a West China School of Pharmacy, Sichuan University , Chengdu , China and.
Chao R; a West China School of Pharmacy, Sichuan University , Chengdu , China and.

Xenobiotica ; 49(1): 71-79, 2019 Jan.

Article em En | MEDLINE | ID: mdl-29228872

Assuntos

Medicamentos de Ervas Chinesas/farmacocinética; Administração Oral; Animais; Líquidos Corporais/química; Cromatografia Líquida de Alta Pressão; Cromatografia Líquida; Fezes/química; Ratos; Ratos Sprague-Dawley; Espectrometria de Massas em Tandem; Distribuição Tecidual

Palavras-chave

Everted rat gut sac; UPLC-MS/MS; excretion; mesaconine; pharmacokinetics; tissue distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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