Noncoded amino acids in protein engineering: Structure-activity relationship studies of hirudin-thrombin interaction.

De Filippis, Vincenzo; Acquasaliente, Laura; Pontarollo, Giulia; Peterle, Daniele

De Filippis, Vincenzo; Acquasaliente, Laura; Pontarollo, Giulia; Peterle, Daniele.

Afiliação

De Filippis V; Laboratory of Protein Chemistry, Department of Pharmaceutical & Pharmacological Sciences, University of Padua, Padua, Italy.
Acquasaliente L; Laboratory of Protein Chemistry, Department of Pharmaceutical & Pharmacological Sciences, University of Padua, Padua, Italy.
Pontarollo G; Laboratory of Protein Chemistry, Department of Pharmaceutical & Pharmacological Sciences, University of Padua, Padua, Italy.
Peterle D; Laboratory of Protein Chemistry, Department of Pharmaceutical & Pharmacological Sciences, University of Padua, Padua, Italy.

Biotechnol Appl Biochem ; 65(1): 69-80, 2018 Jan.

Article em En | MEDLINE | ID: mdl-29230873

Assuntos

Aminoácidos/química; Hirudinas/química; Engenharia de Proteínas; Trombina/química; Aminoácidos/metabolismo; Hirudinas/metabolismo; Modelos Moleculares; Estrutura Molecular; Eletricidade Estática; Relação Estrutura-Atividade; Trombina/metabolismo

Palavras-chave

hirudin; noncoded amino acids; peptide synthesis; protein engineering; protein-protein interactions; thrombin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombina / Engenharia de Proteínas / Hirudinas / Aminoácidos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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