Endothelial cells express NKG2D ligands and desensitize antitumor NK responses.
Elife
; 62017 12 12.
Article
em En
| MEDLINE
| ID: mdl-29231815
ABSTRACT
Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of diseased cells. The responsiveness of NK cells to acute stimulation is dynamically tuned by steady-state receptor-ligand interactions of an NK cell with its cellular environment. Here, we demonstrate that in healthy WT mice the NK activating receptor NKG2D is engaged in vivo by one of its ligands, RAE-1ε, which is expressed constitutively by lymph node endothelial cells and highly induced on tumor-associated endothelium. This interaction causes internalization of NKG2D from the NK cell surface and transmits an NK-intrinsic signal that desensitizes NK cell responses globally to acute stimulation, resulting in impaired NK antitumor responses in vivo.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Melanoma Experimental
/
Endotélio Vascular
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Células Matadoras Naturais
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Linfonodos
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article