Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance.

Wood, Francesca L; Houston, J Brian; Hallifax, David

Wood, Francesca L; Houston, J Brian; Hallifax, David.

Afiliação

Wood FL; Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Houston JB; Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Hallifax D; Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom David.Hallifax@manchester.ac.uk.

Drug Metab Dispos ; 46(3): 268-278, 2018 03.

Article em En | MEDLINE | ID: mdl-29233818

Assuntos

Permeabilidade da Membrana Celular/fisiologia; Hepatócitos/metabolismo; Fígado/metabolismo; Taxa de Depuração Metabólica/fisiologia; Água/metabolismo; Animais; Transporte Biológico/fisiologia; Sistema Enzimático do Citocromo P-450/metabolismo; Cinética; Masculino; Midazolam/metabolismo; NADP/metabolismo; Propranolol/metabolismo; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Saquinavir/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Água / Taxa de Depuração Metabólica / Permeabilidade da Membrana Celular / Hepatócitos / Fígado Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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