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Predictive and Prognostic Brain Metastases Assessment in Luminal Breast Cancer Patients: FN14 and GRP94 from Diagnosis to Prophylaxis.
Martínez-Aranda, Antonio; Hernández, Vanessa; Moreno, Ferran; Baixeras, Núria; Cuadras, Daniel; Urruticoechea, Ander; Gil-Gil, Miguel; Vidal, Noemí; Andreu, Xavier; Seguí, Miquel A; Ballester, Rosa; Castella, Eva; Sierra, Angels.
Afiliação
  • Martínez-Aranda A; Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Hernández V; Departament de Medicina, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Moreno F; Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Baixeras N; Servei d'Oncologia Radioteràpica, Institut Català d'Oncologia (ICO), Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Cuadras D; Servei d'Anatomia Patològica, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Urruticoechea A; Statistical Service, Sant Joan de Déu Research Foundation, Barcelona, Spain.
  • Gil-Gil M; Breast Cancer Unit, Institut Català d'Oncologia - IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Vidal N; Neuroncology Unit, Institut Català d'Oncologia - IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Andreu X; Servei d'Anatomia Patològica, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Seguí MA; Servei d'Anatomia Patològica, Consorci Hospitalari Parc Taulí, Barcelona, Spain.
  • Ballester R; Servei d'Oncología Mèdica, Consorci Hospitalari Parc Taulí, Barcelona, Spain.
  • Castella E; Servei d'Oncología Radioteràpica, Institut Català d'Oncologia (ICO), Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
  • Sierra A; Servei d'Anatomia Patològica de Can Ruti, Institut Català d'Oncologia (ICO), Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
Front Oncol ; 7: 283, 2017.
Article em En | MEDLINE | ID: mdl-29250484
ABSTRACT
FN14 has been implicated in many intracellular signaling pathways, and GRP94 is a well-known endoplasmic reticulum protein regulated by glucose. Recently, both have been associated with metastasis progression in breast cancer patients. We studied the usefulness of FN14 and GRP94 expression to stratify breast cancer patients according their risk of brain metastasis (BrM) progression. We analyzed FN14 and GRP94 by immunohistochemistry in a retrospective multicenter study using tissue microarrays from 208 patients with breast carcinomas, of whom 52 had developed BrM. Clinical and pathological characteristics and biomarkers expression in Luminal and non-Luminal patients were analyzed using a multivariate logistic regression model adjusted for covariates, and brain metastasis-free survival (BrMFS) was estimated using the Kaplan-Meier method and the Cox proportional hazards model. FN14 expression was associated with BrM progression mainly in Luminal breast cancer patients with a sensitivity (53.85%) and specificity (89.60%) similar to Her2 expression (46.15 and 89.84%, respectively). Moreover, the likelihood to develop BrM in FN14-positive Luminal carcinomas increased 36.70-fold (3.65-368.25, p = 0.002). Furthermore, the worst prognostic factor for BrMFS in patients with Luminal carcinomas was FN14 overexpression (HR = 8.25; 95% CI 2.77-24.61; p = 0.00015). In these patients, GRP94 overexpression also increased the risk of BrM (HR = 3.58; 95% CI 0.98-13.11; p = 0.054-Wald test). Therefore, FN14 expression in Luminal breast carcinomas is a predictive/prognostic biomarker of BrM, which combined with GRP94 predicts BrM progression in non-Luminal tumors 4.04-fold (1.19-8.22, p = 0.025), suggesting that both biomarkers are useful to stratify BrM risk at early diagnosis. We propose a new follow-up protocol for the early prevention of clinical BrM of breast cancer patients with BrM risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article