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Enterotypes in the landscape of gut microbial community composition.
Costea, Paul I; Hildebrand, Falk; Arumugam, Manimozhiyan; Bäckhed, Fredrik; Blaser, Martin J; Bushman, Frederic D; de Vos, Willem M; Ehrlich, S Dusko; Fraser, Claire M; Hattori, Masahira; Huttenhower, Curtis; Jeffery, Ian B; Knights, Dan; Lewis, James D; Ley, Ruth E; Ochman, Howard; O'Toole, Paul W; Quince, Christopher; Relman, David A; Shanahan, Fergus; Sunagawa, Shinichi; Wang, Jun; Weinstock, George M; Wu, Gary D; Zeller, Georg; Zhao, Liping; Raes, Jeroen; Knight, Rob; Bork, Peer.
Afiliação
  • Costea PI; European Molecular Biology Laboratory, Heidelberg, Germany.
  • Hildebrand F; European Molecular Biology Laboratory, Heidelberg, Germany.
  • Arumugam M; VIB Center for Microbiology, VIB, Belgium.
  • Bäckhed F; Laboratory of Microbiology, Vrije Universiteit Brussel, Brussels, Belgium.
  • Blaser MJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Bushman FD; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • de Vos WM; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ehrlich SD; New York University Langone Medical Center, New York, NY, USA.
  • Fraser CM; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Hattori M; RPU Immunobiology, Department of Bacteriology & Immunology, University of Helsinki, Helsinki, Finland.
  • Huttenhower C; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
  • Jeffery IB; Metagenopolis, Institut National de la Recherche Agronomique, Jouy en Josas, France.
  • Knights D; King's College London, Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy's Hospital, London, UK.
  • Lewis JD; Institute for Genome Sciences at the University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ley RE; Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
  • Ochman H; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
  • O'Toole PW; APC Microbiome Institute, University College Cork, Cork, Ireland.
  • Quince C; Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA.
  • Relman DA; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.
  • Shanahan F; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sunagawa S; MPI Department of Microbiome Science, Tübingen, Germany.
  • Wang J; Department of Integrative Biology, University of Texas, Austin, TX, USA.
  • Weinstock GM; APC Microbiome Institute, University College Cork, Cork, Ireland.
  • Wu GD; Warwick Medical School, University of Warwick, Coventry, UK.
  • Zeller G; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
  • Zhao L; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Raes J; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
  • Knight R; APC Microbiome Institute, University College Cork, Cork, Ireland.
  • Bork P; European Molecular Biology Laboratory, Heidelberg, Germany.
Nat Microbiol ; 3(1): 8-16, 2018 Jan.
Article em En | MEDLINE | ID: mdl-29255284
ABSTRACT
Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Trato Gastrointestinal / Metagenoma / Microbioma Gastrointestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Trato Gastrointestinal / Metagenoma / Microbioma Gastrointestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article