PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by ß<sub>2</sub>-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone, Timothy B; Smith, Kaitlyn H; Koziol-White, Cynthia J; Li, Fengying; Kazarian, Austin G; Corpuz, Maia L; Shumyatcher, Maya; Ehlert, Frederick J; Himes, Blanca E; Panettieri, Reynold A; Ostrom, Rennolds S

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by ß₂-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone, Timothy B; Smith, Kaitlyn H; Koziol-White, Cynthia J; Li, Fengying; Kazarian, Austin G; Corpuz, Maia L; Shumyatcher, Maya; Ehlert, Frederick J; Himes, Blanca E; Panettieri, Reynold A; Ostrom, Rennolds S.

Afiliação

Johnstone TB; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Smith KH; 2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Koziol-White CJ; 3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Li F; 2 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Kazarian AG; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Corpuz ML; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.
Shumyatcher M; 4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Ehlert FJ; 5 Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California.
Himes BE; 4 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Panettieri RA; 3 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey.
Ostrom RS; 1 Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California.

Am J Respir Cell Mol Biol ; 58(4): 530-541, 2018 04.

Article em En | MEDLINE | ID: mdl-29262264

Assuntos

3',5'-AMP Cíclico Fosfodiesterases/metabolismo; Adenilil Ciclases/metabolismo; Asma/enzimologia; AMP Cíclico/metabolismo; Músculo Liso/enzimologia; Miócitos de Músculo Liso/enzimologia; Receptores Adrenérgicos beta 2/metabolismo; Sistema Respiratório/enzimologia; 3',5'-AMP Cíclico Fosfodiesterases/genética; Adenilil Ciclases/genética; Remodelação das Vias Aéreas; Asma/genética; Asma/patologia; Asma/fisiopatologia; Estudos de Casos e Controles; Proliferação de Células; Células Cultivadas; Humanos; Microdomínios da Membrana/enzimologia; Microdomínios da Membrana/patologia; Músculo Liso/patologia; Músculo Liso/fisiopatologia; Miócitos de Músculo Liso/patologia; Receptores Adrenérgicos beta 2/genética; Sistema Respiratório/patologia; Sistema Respiratório/fisiopatologia; Sistemas do Segundo Mensageiro; Fatores de Tempo

Palavras-chave

PDE; adenylyl cyclase; cAMP compartmentation; lipid rafts

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Respiratório / Asma / Adenilil Ciclases / Receptores Adrenérgicos beta 2 / AMP Cíclico / 3',5'-AMP Cíclico Fosfodiesterases / Miócitos de Músculo Liso / Músculo Liso Tipo de estudo: Observational_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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