The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism.

Yangyuoru, Philip M; Bradburn, Devin A; Liu, Zhonghua; Xiao, Tsan Sam; Russell, Rick

Yangyuoru, Philip M; Bradburn, Devin A; Liu, Zhonghua; Xiao, Tsan Sam; Russell, Rick.

Afiliação

Yangyuoru PM; From the Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 and.
Bradburn DA; From the Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 and.
Liu Z; the Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Xiao TS; the Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Russell R; From the Department of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 and rick_russell@cm.utexas.edu.

J Biol Chem ; 293(6): 1924-1932, 2018 02 09.

Article em En | MEDLINE | ID: mdl-29269411

Assuntos

RNA Helicases DEAD-box/genética; DNA/química; Quadruplex G; RNA Helicases DEAD-box/química; RNA Helicases DEAD-box/metabolismo; DNA/genética; Humanos; Cinética; RNA/química; RNA/genética

Palavras-chave

G-quadruplex; RNA folding; RNA helicase; enzyme kinetics; enzyme mechanism; pre-steady-state kinetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / RNA Helicases DEAD-box / Quadruplex G Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google