Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors.

Al-Balas, Qosay A; Hassan, Mohammad A; Al-Shar'i, Nizar A; El-Elimat, Tamam; Almaaytah, Ammar M

Al-Balas, Qosay A; Hassan, Mohammad A; Al-Shar'i, Nizar A; El-Elimat, Tamam; Almaaytah, Ammar M.

Afiliação

Al-Balas QA; Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Hassan MA; Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Al-Shar'i NA; Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid, 22110, Jordan.
El-Elimat T; Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Almaaytah AM; Department of Pharmaceutical Technology, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Drug Dev Res ; 79(2): 58-69, 2018 03.

Article em En | MEDLINE | ID: mdl-29285772

Assuntos

Flavonoides/química; Flavonoides/farmacologia; Lactoilglutationa Liase/antagonistas & inibidores; Lactoilglutationa Liase/química; Lactoilglutationa Liase/genética; Lactoilglutationa Liase/metabolismo; Simulação de Acoplamento Molecular; Estrutura Molecular; Conformação Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Relação Estrutura-Atividade

Palavras-chave

flavonoids; glyoxalase-I; metalloenzyme; molecular docking; structure-activity relationship; zinc-chelation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Lactoilglutationa Liase Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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