Intracranial metastasis in fibrolamellar hepatocellular carcinoma.
Pediatr Blood Cancer
; 65(4)2018 04.
Article
em En
| MEDLINE
| ID: mdl-29286561
Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1-PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Carcinoma Hepatocelular
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Procedimentos Neurocirúrgicos
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Neuroimagem
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Neoplasias Hepáticas
Limite:
Adolescent
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article