Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies.

Kaushik, Sanket; Iqbal, Naseer; Singh, Nagendra; Sikarwar, Juhi S; Singh, Prashant K; Sharma, Pradeep; Kaur, Punit; Sharma, Sujata; Owais, Mohammad; Singh, Tej P

Kaushik, Sanket; Iqbal, Naseer; Singh, Nagendra; Sikarwar, Juhi S; Singh, Prashant K; Sharma, Pradeep; Kaur, Punit; Sharma, Sujata; Owais, Mohammad; Singh, Tej P.

Afiliação

Kaushik S; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Iqbal N; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Singh N; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Sikarwar JS; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Singh PK; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Sharma P; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Kaur P; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Sharma S; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Owais M; Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
Singh TP; Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India tpsingh.aiims@gmail.com.

Biochem J ; 475(3): 547-560, 2018 02 09.

Article em En | MEDLINE | ID: mdl-29301982

Assuntos

Acinetobacter baumannii/enzimologia; Biofilmes/efeitos dos fármacos; Hidrolases de Éster Carboxílico/química; Hidrolases de Éster Carboxílico/genética; Acinetobacter baumannii/química; Acinetobacter baumannii/genética; Antibacterianos/química; Antibacterianos/farmacologia; Sítios de Ligação; Hidrolases de Éster Carboxílico/farmacologia; Catálise; Domínio Catalítico; Cristalografia por Raios X; Citarabina/química; Escherichia coli/genética; Domínios Proteicos; RNA de Transferência/química; RNA de Transferência/genética; Aminoacil-RNA de Transferência/genética; Especificidade por Substrato; Propriedades de Superfície

Palavras-chave

crystal structure; cytarabine; peptidyl-tRNA hydrolase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hidrolases de Éster Carboxílico / Biofilmes / Acinetobacter baumannii Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google