Arterial stiffness and peripheral vascular resistance in offspring of hypertensive parents: influence of sex and other confounders.
J Hypertens
; 36(4): 815-823, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29303831
ABSTRACT
AIM:
Established essential hypertension is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for essential hypertension is uncertain.METHODS:
Participants from the Danish Hypertension Prevention Project (DHyPP) (both parents hypertensive) (nâ=â95, 41â±â1 years, 53% men) were compared with available spouses (nâ=â45, 41â±â1 years) using measurements of ambulatory blood pressure (BP), left ventricular mass index (LVMI), pulse wave velocity, central BP and augmentation index (AIx) in addition to forearm resting and minimal resistance [forearm resting vascular resistance (Rrest) and forearm minimal vascular resistance (Rmin)].RESULTS:
DHyPP patients with participating spouses had higher 24-h mean BP (94â±â1 vs. 88â±â1âmmHg, Pâ<â0.01), LVMI (94â±â3 vs. 80â±â2âg/m, Pâ<â0.01), central SBP (121â±â2 vs. 111â±â2âmmHg, Pâ<â0.01) and AIx (16.0â±â1.2 vs. 10.5â±â1.7%, Pâ<â0.01), but similar carotid-femoral pulse wave velocity (7.5â±â0.2 vs. 7.1â±â0.2âm/s), Rrest (53â±â3 vs. 51â±â3âmmHg/ml/min/100âml) and log Rmin (0.58â±â0.02 vs. 0.55â±â0.02âmmHg/ml/min/100âml) when compared with spouses. Using multiple linear regression analysis (adjusting for sex, age, BMI, creatinine clearance and 24-h BP, heart rate and sodium excretion) AIx and LVMI remained elevated in DHyPP patients [4.2% (0.7; 7.7), Pâ=â0.02 and 6.3âg/m (0.7; 11.9), Pâ=â0.03]. For the entire DHyPP cohort AIx, Rrest and Rmin were higher in women than men (Pâ<â0.01), and the same was true for AIx and Rmin among spouses (Pâ<â0.05). Furthermore, AIx was linearly associated with Rrest and Rmin.CONCLUSION:
Young to middle-aged individuals genetically predisposed for essential hypertension display increased AIx and LVMI, although vascular stiffness and peripheral resistance are still normal.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência Vascular
/
Predisposição Genética para Doença
/
Rigidez Vascular
/
Hipertensão Essencial
/
Ventrículos do Coração
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article