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New lignans attenuating cognitive deterioration of Aß transgenic flies discovered in Acorus tatarinowii.
Zhang, Wei-Yang; Feng, Xiao-Lin; Lu, Dan; Gao, Hao; Yu, Yang; Yao, Xin-Sheng.
Afiliação
  • Zhang WY; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, PR China.
  • Feng XL; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Lu D; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Gao H; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Yu Y; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • Yao XS; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: 1018yuyang@163.com.
Bioorg Med Chem Lett ; 28(4): 814-819, 2018 02 15.
Article em En | MEDLINE | ID: mdl-29307497
ABSTRACT
Five new lignan racemates, (±)-tatarinoid D-H (1-5), and three known analogues (6-8) were isolated from the rhizomes of Acorus tatarinowii. Their structures were established by 1D, 2D-NMR, HR-MS, IR and optical spectral data. Among them, 1 and 6-8 can alleviate the cognitive deterioration of Aß transgenic flies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lignanas / Nootrópicos / Disfunção Cognitiva Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lignanas / Nootrópicos / Disfunção Cognitiva Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article