Efficacy and safety of remifentanil for analgesia in cesarean delivery.
Medicine (Baltimore)
; 96(48): e8341, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29310326
ABSTRACT
BACKGROUND:
This study aimed to assess the efficacy and safety of remifentanil as a general anesthetic during cesarean delivery. MATERIAL ANDMETHODS:
Fifty women with singleton pregnancies undergoing cesarean delivery were randomly divided into intervention and control groups, each group containing 25 subjects. Participants in the intervention group received remifentanil (infused at 2âµg/kg/h), whereas subjects in the control group were given dexmedetomidine (infused at 0.4âµg/kg/h). Outcome measurements included mean arterial blood pressure (MAP), heart rate (HR), bispectral index (BIS), Apgar scores at 1 and 5âminutes, and the pH, PCO2, PO2, and base excess (BE) of umbilical venous and arterial blood.RESULTS:
Forty-four participants completed the study. Patients in the intervention group did not experience greater effect and safety than those in the control group (Pâ>â.05), although MAP and BIS values decreased significantly immediately before laryngoscopy (Pâ<â.05). In addition, BIS values were reduced significantly at the time of skin incision, at uterine incision, and immediately after fetal delivery when compared with baseline values in both groups (Pâ<â.01).CONCLUSION:
This study concluded that remifentanil and dexmedetomidine exhibited similar efficacy and safety during general anesthesia for cesarean delivery.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Cesárea
/
Analgésicos Opioides
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article