Inherited Cancer in the Age of Next-Generation Sequencing.
Biol Res Nurs
; 20(2): 192-204, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29325452
ABSTRACT
Next-generation sequencing (NGS) technology has led to the ability to test for multiple cancer susceptibility genes simultaneously without significantly increasing cost or turnaround time. With growing usage of multigene testing for inherited cancer, ongoing education for nurses and other health-care providers about hereditary cancer screening is imperative to ensure appropriate testing candidate identification, test selection, and posttest management. The purpose of this review article is to (1) provide an overview of how NGS works to detect germline mutations, (2) summarize the benefits and limitations of multigene panel testing, (3) describe risk categories of cancer susceptibility genes, and (4) highlight the counseling considerations for patients pursuing multigene testing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes Genéticos
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Predisposição Genética para Doença
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Sequenciamento de Nucleotídeos em Larga Escala
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article