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Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases.
Schulz, Robert; Atef, Amira; Becker, Daniel; Gottschalk, Franziska; Tauber, Carolin; Wagner, Stefan; Arkona, Christoph; Abdel-Hafez, Atef A; Farag, Hassan H; Rademann, Jörg; Wolber, Gerhard.
Afiliação
  • Schulz R; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Atef A; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University , Assiut 71526, Egypt.
  • Becker D; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Gottschalk F; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Tauber C; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Wagner S; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Arkona C; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Abdel-Hafez AA; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University , Assiut 71526, Egypt.
  • Farag HH; Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University , Assiut 71526, Egypt.
  • Rademann J; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
  • Wolber G; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Freie Universität Berlin , Königin-Luise Straße 2+4, Berlin 14195, Germany.
J Med Chem ; 61(3): 1218-1230, 2018 02 08.
Article em En | MEDLINE | ID: mdl-29328649
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Cisteína Endopeptidases / Inibidores de Cisteína Proteinase / Enterovirus / Cetonas Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Cisteína Endopeptidases / Inibidores de Cisteína Proteinase / Enterovirus / Cetonas Idioma: En Ano de publicação: 2018 Tipo de documento: Article