Effect of Porphyromonas gingivalis infection in the placenta and umbilical cord in pregnant mice with low birth weight.
Acta Odontol Scand
; 76(6): 433-441, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29334319
ABSTRACT
OBJECTIVE:
Growing evidence indicates an association between periodontitis and delivery outcome; however, the mechanism is unclear. This study aimed to investigate the influence of Porphyromonas gingivalis (Pg) infection on delivery outcome in mice. MATERIALS ANDMETHODS:
Bacteremia was induced in pregnant SlcICR mice (8 weeks old) by intravenous injection of Pg. Mice were randomly divided into a control group (CO), and those receiving Pg injection at gestational day 1 (GD1), gestational day 15 (GD15) or every day (ED). Delivery outcome, Pg infection, and gene expression in the placenta and umbilical cord were evaluated.RESULTS:
Birth weight was lower in the ED and GD15 groups than in the CO group. A remarkable increase in anti-Pg IgG antibody was observed in the ED and GD1 groups, although Pg was not detected in the placenta or umbilical cord. mRNA expression of Tnfα and Il6 in the placenta, and Hif1α in the umbilical cord, was significantly increased in the ED group. Microarray analysis of the umbilical cord revealed increased expression of several genes including Orm1, Mgl2, Rps6ka3 and Trim15 in the ED group.CONCLUSIONS:
Pg infection during the third trimester caused low birth weight and inflammation in the placenta and umbilical cord.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Placenta
/
Cordão Umbilical
/
Peso ao Nascer
/
Prenhez
/
Porphyromonas gingivalis
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article