Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells.
Nat Immunol
; 19(2): 192-201, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29335647
ABSTRACT
Pulmonary immunity requires tight regulation, as interstitial inflammation can compromise gas exchange and lead to respiratory failure. Here we found a greater number of aged CD11bhiL-selectinloCXCR4+ polymorphonuclear leukocytes (PMNs) in lung vasculature than in the peripheral circulation. Using pulmonary intravital microscopy, we observed lung PMNs physically interacting with B cells via ß2 integrins; this initiated neutrophil apoptosis, which led to macrophage-mediated clearance. Genetic deletion of B cells led to the accumulation of aged PMNs in the lungs without systemic inflammation, which caused pathological fibrotic interstitial lung disease that was attenuated by the adoptive transfer of B cells or depletion of PMNs. Thus, the lungs are an intermediary niche in the PMN lifecycle wherein aged PMNs are regulated by B cells, which restrains their potential to cause pulmonary pathology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose Pulmonar
/
Linfócitos B
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Doenças Pulmonares Intersticiais
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Neutrófilos
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article