Curcumin attenuates myocardial ischemia-reperfusion injury.
Oncotarget
; 8(67): 112051-112059, 2017 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-29340110
ABSTRACT
BACKGROUND:
Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.METHODS:
Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. RESULTS ANDCONCLUSIONS:
The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article